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Frequently Asked Questions
You should not use this medicine if you have severe kidney disease, metabolic acidosis, or diabetic ketoacidosis (call your doctor for treatment).
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
Metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Metformin is sometimes used together with insulin or other medications, but metformin is not for treating type 1 diabetes.
Metformin may also be used for purposes not listed in this medication guide.
You should not use metformin if you are allergic to it, or if you have:
- severe kidney disease; or
- metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin. Be sure your caregivers know ahead of time that you are using this medication.
Tell your doctor if you have ever had:
- kidney disease (your kidney function may need to be checked before you take this medicine);
- high ketone levels in your blood or urine;
- heart disease, congestive heart failure;
- liver disease; or
- if you also use insulin, or other oral diabetes medications.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.
Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
You should not breastfeed while using this medicine.
Metformin should not be given to a child younger than 10 years old. Some forms of metformin are not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take metformin with a meal, unless your doctor tells you otherwise. Some forms of metformin are taken only once daily with the evening meal. Follow your doctor's instructions.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.
You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).
Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Metformin is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
Your doctor may have you take extra vitamin B12 while you are taking metformin. Take only the amount of vitamin B12 that your doctor has prescribed.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people using metformin develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:
- unusual muscle pain;
- feeling cold;
- trouble breathing;
- feeling dizzy, light-headed, tired, or very weak;
- stomach pain, vomiting; or
- slow or irregular heart rate.
Common side effects may include:
- low blood sugar;
- nausea, upset stomach; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can affect metformin, making this medicine less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Your pharmacist can provide more information about metformin.
|Brand Name Examples||Supplied As||Strength|
|Glumetza||Tablet ER Gastric Retention 24 Hr||1000 Mg500 Mg|
|Riomet||Solution Oral||500 Mg/5Ml|
|Riomet ER||Suspension ER Recon||500 Mg/5Ml|
|Generic Examples||Supplied As||Strength|
|MetFORMIN (Eqv-Fortamet)||Tablet ER 24 Hr||500 Mg1000 Mg|
|MetFORMIN (Eqv-Glucophage XR)||Tablet ER 24 Hr||500 Mg|
|MetFORMIN (Eqv-Glumetza)||Tablet ER Gastric Retention 24 Hr||1000 Mg500 Mg|
|Metformin Er Gastric||Tablet ER Gastric Retention 24 Hr||500 Mg1000 Mg|
|Metformin Hcl||Tablet||850 Mg1000 Mg500 Mg625 Mg|
|Solution Oral||500 Mg/5Ml|
|Metformin Hcl Er||Tablet ER 24 Hr||500 Mg750 Mg|
|MetFORMIN Hydrochloride||Tablet||1000 Mg850 Mg500 Mg|
|Solution Oral||500 Mg/5Ml|
|MetFORMIN Hydrochloride ER||Tablet ER 24 Hr||750 Mg|