Amphotericin B

Amphotericin should be used only to treat serious, possibly fatal fungal infections. This medication should not be used for less severe infections in limited areas of the body (such as fungal infection of the mouth/esophagus, vaginal yeast infections) in patients with normal white blood cell counts.

This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used to reduce the risk of fungal infections in people with fevers and low white blood cell (neutrophil) counts or people with weakened immune systems (such as due to HIV, organ transplant, or cancer).

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: anti-cancer drugs (such as mechlorethamine, nitrogen mustard), azole antifungals (such as ketoconazole, itraconazole), cidofovir, digoxin, flucytosine, medications that affect the kidneys (including pentamidine, tacrolimus, aminoglycosides such as gentamicin), muscle relaxants (such as tubocurarine), zidovudine.

Lab and/or medical tests (such as kidney/liver function, potassium/magnesium levels, complete blood counts) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

This medication is usually given by injection into a vein as directed by your doctor, usually once a day or every other day. It should be injected slowly over 2 to 6 hours. Your doctor may give you a smaller dose first to test your response to the medication. The dosage is based on your medical condition, weight, response to the test dose, and response to treatment. If this medication is stopped for 7 days or longer, then it should be restarted at the lowest dose and slowly increased.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Infusion reactions may happen during the infusion of this drug. Your doctor may prescribe other medications (including acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) before each treatment to help prevent these side effects. Tell your doctor right away if you have any symptoms of infusion reactions such as fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing. Your doctor may give you other medications to help with these side effects.

It may be necessary to continue this medication for several weeks to several months in order to treat certain infections. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Before using amphotericin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: white blood cell (leukocyte) transfusions, heart disease (such as irregular heartbeat, heart failure), liver disease, kidney disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: dizziness, fainting, slow heartbeat, trouble breathing.