Perphenazine/Amitriptyline Hcl

What is Amitriptyline-Perphenazine used for?

This combination medication is used to treat depression occurring with other mental/mood disorders (such as anxiety, agitation, schizophrenia). Perphenazine belongs to a class of drugs known as antipsychotics. Amitriptyline belongs to a class of drugs known as tricyclic antidepressants. Perphenazine/amitriptyline works by helping to restore the balance of certain natural substances in the brain.


Perphenazine/Amitriptyline Hcl


Mental/Neuro Disorders
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Amitriptyline-Perphenazine Frequently Asked Questions

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Amitriptyline-Perphenazine Dosage and Form Information

2 Mg-10 Mg
4 Mg-50 Mg
4 Mg-25 Mg
2 Mg-25 Mg