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Sodium Phenylbutyrate

What is Olpruva used for?

This medication is used along with diet changes for long-term treatment of a certain inherited disorder (urea cycle disorder). Sodium phenylbutyrate helps remove a certain chemical (ammonia) from the body. Too much ammonia in the body can cause brain damage and sometimes death. This medication should not be used to treat sudden, severely high levels of ammonia in the body. Get medical help right away if you have sudden symptoms of too much ammonia (such as trouble thinking, nausea, vomiting, irritability, trouble speaking, trouble walking, fainting).


Sodium Phenylbutyrate


Enzyme Deficiencies
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Olpruva Frequently Asked Questions

Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start taking sodium phenylbutyrate and each time you get a refill. Follow the illustrated directions for the proper use of this medication. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth exactly as directed by your doctor. The dosage is based on your weight or body size, medical condition, and response to treatment. The total daily dose should be divided into equal amounts and taken with each meal or feeding (such as 3 to 6 times daily). Do not increase or decrease your dose without your doctor's approval.

This medication must be mixed as directed before taking. To prepare a dose, pour the contents of the thickening packet into a cup with 4 ounces/120 milliliters of water. Stir well for at least 30 seconds until the water thickens. Then, open the packet(s) containing sodium phenylbutyrate and pour its contents into the cup with the thickened water mixture. Stir well for 15 seconds and drink all of the mixture within 5 minutes of mixing. Add more water to the cup, stir, and drink all of the mixture to make sure you are getting the entire dose. Discard mixture after 30 minutes. Do not prepare a supply in advance. Do not give through a feeding tube.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Olpruva Dosage and Form Information

Pellets In Packet
5 G
2 G
4 G
3 G
6 G
6.67 G