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Isocarboxazid is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain. Isocarboxazid is used to treat symptoms of depression that may include anxiety, panic, or phobias. Isocarboxazid is usually given after other antidepressants have been tried without successful treatment of symptoms. Isocarboxazid may also be used for purposes not listed in this medication guide.
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Frequently Asked Questions

There are many other medicines that can cause serious medical problems or death if you take them together with isocarboxazid. Before taking isocarboxazid, tell your doctor about all medicines you have used within the past 5 weeks.

Do not use isocarboxazid if you have used another MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include linezolid, methylene blue injection, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine, and others.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using isocarboxazid. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

While you are taking isocarboxazid, you must not drink alcohol or eat foods that are high in tyramine, listed in the "What should I avoid while taking isocarboxazid?" section of this leaflet. Eating tyramine while you are taking isocarboxazid can raise your blood pressure to dangerous levels.

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Brand Name Examples Supplied As Strength
Marplan Tablet 10 Mg

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