Granix
Tbo-Filgrastim
What is Granix used for?
Filgrastim is a man-made version of a certain natural substance made by your body. It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Filgrastim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy, chronic neutropenia, or exposure to large amounts of radiation). It is also used in certain treatment procedures (such as bone marrow/stem cell transplant). This monograph is about the following filgrastim products: filgrastim, filgrastim-aafi, filgrastim-ayow, filgrastim-sndz, filgrastim-txid, and tbo-filgrastim.
CHEMICAL NAME
DRUG TYPE
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What does Granix look like?
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Dizziness, headache, and aching or pain in the bones, joints, and muscles may occur. Taking a non-aspirin pain reliever such as acetaminophen may help relieve pain. Ask your doctor or pharmacist for more details. Redness, swelling, itching, or bruising at the injection site may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, pink/bloody urine, bloody vomit, coughing up blood, fast heartbeat, fever, purple/red spots on your skin, back pain.
Get medical help right away if you have any very serious side effects, including: breathing problems (such as fast breathing, shortness of breath), unusual decrease in urination, unusual tiredness, swelling/puffiness of the body.
Rarely, serious (possibly fatal) damage to the spleen may occur. Get medical help right away if you develop stomach/abdominal pain or shoulder pain.
Rarely, this medication may increase the risk of developing a certain bone marrow disorder (myelodysplastic syndrome-MDS) or blood cancer (acute myeloid leukemia-AML) in people with congenital neutropenia or in people with breast or lung cancer who are receiving chemotherapy/radiation. Ask your doctor for more details.
Filgrastim can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using filgrastim and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Depending on your filgrastim product, this medication is injected under the skin or into a vein. Use as directed by your doctor, usually once a day. The dosage and length of treatment are based on your medical condition, weight, lab tests, and response to treatment.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. Take the medication out of the refrigerator at least 30 minutes before you inject it to allow it to reach room temperature. Do not shake the medication. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. If you are injecting this drug under the skin, first clean the skin you are going to inject into (the injection site) with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into skin that is bruised, tender, red, hard, or that has scars or stretch marks. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.
Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.
If you are receiving cancer chemotherapy, you should not use this medication within 24 hours before or 24 hours after chemotherapy. Ask your doctor for specific directions about when to use this medication.