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Frequently Asked Questions
Oxaprozin can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Oxaprozin may also cause stomach or intestinal bleeding, which can be fatal.
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis in adults. Oxaprozin is also used to treat rheumatoid arthritis in children who are at least 6 years old.
Oxaprozin may also be used for purposes not listed in this medication guide.
Oxaprozin can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Oxaprozin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using oxaprozin, especially in older adults.
You should not use oxaprozin if you are allergic to it, or if you have:
- active bleeding in your stomach or intestines; or
- a history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Tell your doctor if you have ever had:
- heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
- a heart attack, stroke, or blood clot;
- stomach ulcers or bleeding;
- liver or kidney disease; or
- fluid retention.
If you are pregnant, you should not take oxaprozin unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Oxaprozin is not approved for use by anyone younger than 6 years old.
Follow all directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition.
Oxaprozin doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.
If you use this medicine long-term, you may need frequent medical tests.
Store oxaprozin at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding.
Avoid taking aspirin while you are taking oxaprozin.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to oxaprozin (such as aspirin, ibuprofen, ketoprofen, or naproxen).
Oxaprozin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing or difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Stop using oxaprozin and call your doctor at once if you have:
- a skin rash, no matter how mild;
- heart problems--swelling, rapid weight gain, feeling short of breath;
- signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
- low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Common side effects may include:
- nausea, upset stomach;
- diarrhea, constipation; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ask your doctor before using oxaprozin if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your other medicines, especially:
- a blood thinner (warfarin, Coumadin, Jantoven);
- heart or blood pressure medication, including a diuretic or "water pill"; or
- steroid medicine (such as prednisone).
This list is not complete. Other drugs may affect oxaprozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Your pharmacist can provide more information about oxaprozin.
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