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Before taking naloxegol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal blockage, stomach/intestinal ulcers or tumors, bowel disease (such as Crohn's, diverticulitis), kidney disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, naloxegol should be used only when clearly needed. This medication may cause opioid withdrawal in a pregnant woman and her unborn baby. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. This medication may cause opioid withdrawal in a nursing infant. Consult your doctor before breastfeeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of naloxegol from your body, which may affect how naloxegol works. Examples include adagrasib, azole antifungals (such as ketoconazole, itraconazole), clarithromycin, cobicistat, indinavir, nefazodone, nelfinavir, rifamycins (such as rifampin, rifabutin), ritonavir, tipranavir, among others.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669.

Do not share this medication with others.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Read the Medication Guide provided by your pharmacist before you start taking naloxegol and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth on an empty stomach at least 1 hour before or 2 hours after a meal, as directed by your doctor, usually once daily in the morning.

If you are unable to swallow this medication whole, you may crush the tablets to a powder, mix in 4 ounces (120 milliliters) of water and drink immediately. Refill the glass with another 4 ounces of water, stir the contents and drink it.

If you are giving this medication through a tube into the stomach (nasogastric tube), ask you health care professional for detailed instructions on how to properly mix and give it.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Naloxegol is used only for constipation caused by opioids. Stop using this medication when you stop taking opioid pain medication unless otherwise directed by your doctor.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Stop taking other laxatives before you start treatment with naloxegol. Your doctor may direct you to take other laxatives if your condition does not get better after 3 days of treatment with naloxegol. Ask your doctor for more details and follow your doctor's instructions carefully.

Tell your doctor if your constipation lasts or gets worse.