Nityr
Nitisinone
What is Nityr used for?
Nitisinone is used to treat a certain inherited disorder (hereditary tyrosinemia type 1, also known as HT-1). HT-1 is usually discovered in infants and needs lifelong treatment. This condition is caused by a shortage of a certain natural substance that is needed to break down a nutrient (tyrosine) found in food. This effect causes a build-up of too much tyrosine and related substances in the liver. Nitisinone works by helping to prevent the formation and build-up of several toxic substances that cause damage to the liver, kidneys, and nervous system. This drug must be used along with a diet low in protein, tyrosine, and phenylalanine.
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Nityr Frequently Asked Questions
The suspension may cause headache, upset stomach, or diarrhea. If any of these effects occur, tell your doctor or pharmacist promptly and discuss switching to other forms of nitisinone.
Remember that this medication has been prescribed because the doctor has judged that the benefit is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may rarely cause a low number of blood cells such as white cells and platelets. This effect can decrease your body's ability to fight an infection or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding.
Your condition and this medication can cause liver problems. Tell the doctor right away if any of these symptoms of liver problems occur: nausea or vomiting that doesn't stop, severe stomach/abdominal pain, yellowing eyes/skin, dark urine.
Your condition and this medication can cause high levels of tyrosine in the blood. It is very important to follow the low protein/low tyrosine diet recommended by your doctor. See also Precautions section. Too much tyrosine may cause skin, eye, or brain problems. Tell the doctor right away if any of these symptoms occur: eye redness/itching/discharge, vision changes, eye pain, eye sensitivity (especially to light), dry/itchy skin, sores on palms of hands/soles of feet, developmental delays (such as holding head up, rolling over, crawling).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact the doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the Patient Information Leaflet if available from your pharmacist before you start taking nitisinone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually twice daily.
If you are taking the capsules, take them on an empty stomach at least 1 hour before or 2 hours after a meal. If you are unable to swallow the capsules, you may open the capsules and mix the contents in a small amount of water, formula, or apple sauce. Take the mixture right away.
If you are taking the suspension, you may take the suspension with or without food. Shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. When using an unopened bottle of suspension for the first time, remove it from the refrigerator and let it warm to room temperature for 30 to 60 minutes before use.
If you are taking the tablets, you may take the tablets with or without food. If you are unable to swallow the tablets, you may crush the tablets and mix them in a small amount of water or applesauce. Take the mixture right away. If you are using a special measuring device/syringe to prepare and give the tablets mixed with water, carefully follow the directions from the manufacturer. Ask your doctor or pharmacist if you have any questions.
The dosage is based on your medical condition, weight, and response to treatment. Your doctor may adjust your dose and schedule based on your response to treatment. Carefully follow your doctor's directions for taking this medication.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
It is very important that patients taking this medication follow a special diet low in protein, tyrosine, and phenylalanine. Consult your doctor, pharmacist, or dietician for more details. (See also Drug Interactions and Precautions sections.)