Learn more about price differences between brand and generic drugs
Get the Inside Rx app
Frequently Asked Questions
MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.
Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Morphine is an opioid medicine used to treat moderate to severe pain. Short-acting morphine is taken as needed for pain.
The extended-release form of morphine is for around-the-clock treatment of pain. This form of morphine is not for use on an as-needed basis for pain.
Morphine may also be used for purposes not listed in this medication guide.
You should not take this medicine if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have:
- severe asthma or breathing problems;
- a stomach or bowel obstruction (including paralytic ileus); or
- if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Tell your doctor if you have ever had:
- breathing problems, sleep apnea (breathing stops during sleep);
- a head injury, brain tumor, or seizures;
- a drug or alcohol addiction, or mental illness;
- urination problems;
- liver or kidney disease; or
- problems with your gallbladder, pancreas, or thyroid.
If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.
Follow the directions on your prescription label and read all medication guides. Never use morphine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.
Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.
Stop taking all other around-the-clock narcotic pain medications when you start taking morphine.
Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Never crush or break a morphine pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of morphine and similar prescription drugs.
Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.
Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
Morphine is sometimes taken only once per day, and sometimes 2 or 3 times per day. Since morphine is used for pain, you are not likely to miss a dose. If you do miss a dose, take the medicine as soon as you remember. Then take your next dose as follows:
- If you take morphine 3 times per day: Take your next dose 8 hours after taking the missed dose.
- If you take morphine 2 times per day: Take your next dose 12 hours after taking the missed dose.
- If you take morphine 1 time per day: Take your next dose 24 hours after taking the missed dose.
Do not take two doses at one time. Do not take more than your prescribed dose in a 24-hour period.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.
Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.
Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
- slow heart rate, sighing, weak or shallow breathing, breathing that stops;
- chest pain, fast or pounding heartbeats;
- extreme drowsiness, feeling like you might pass out;
- high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or
- low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
- drowsiness, dizziness, tiredness;
- constipation, stomach pain, nausea, vomiting;
- sweating; or
- feelings of extreme happiness or sadness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
- other opioids--opioid pain medicine or prescription cough medicine;
- a sedative like Valium--diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others;
- drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, tranquilizer, antidepressant, or antipsychotic medicine; or
- drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.
This list is not complete. Other drugs may affect morphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Your doctor or pharmacist can provide more information about morphine.
|Brand Name Examples||Supplied As||Strength|
|Arymo ER||tablet, extended release||15 mg/8 to 12 hr30 mg/8 to 12 hr60 mg/8 to 12 hr|
|Kadian||capsule, extended release||10 mg/12 to 24 hr100 mg/12 to 24 hr20 mg/12 to 24 hr200 mg/12 to 24 hr30 mg/12 to 24 hr40 mg/12 to 24 hr50 mg/12 to 24 hr60 mg/12 to 24 hr80 mg/12 to 24 hr|
|MorphaBond ER||tablet, extended release||100 mg/8 to 12 hr15 mg/8 to 12 hr30 mg/8 to 12 hr60 mg/8 to 12 hr|
|MS Contin||tablet, extended release||100 mg/8 to 12 hr15 mg/8 to 12 hr200 mg/8 to 12 hr30 mg/8 to 12 hr60 mg/8 to 12 hr|
|Generic Examples||Supplied As||Strength|
|Morphine Sulfate ER||capsule, extended release||10 mg/12 to 24 hr100 mg/12 to 24 hr120 mg/24 hours20 mg/12 to 24 hr30 mg/12 to 24 hr30 mg/24 hours40 mg/12 to 24 hr45 mg/24 hours50 mg/12 to 24 hr60 mg/12 to 24 hr60 mg/24 hours75 mg/24 hours80 mg/12 to 24 hr90 mg/24 hours|
|tablet, extended release||100 mg/8 to 12 hr15 mg/8 to 12 hr200 mg/8 to 12 hr30 mg/8 to 12 hr60 mg/8 to 12 hr|