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Diclofenac Sodium-Misoprostol

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause pain and inflammation. Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by NSAIDs. Diclofenac and misoprostol is a combination medicine used to treat osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers. Diclofenac and misoprostol may also be used for purposes not listed in this medication guide.
nonsteroidal anti-inflammatory agents


Frequently Asked Questions

Do not use if you are pregnant. Misoprostol can cause birth defects, miscarriage, premature labor, or rupture of the uterus. You must have a negative pregnancy test within 2 weeks before you start taking diclofenac and misoprostol. You may need to start taking this medicine only on the 2nd or 3rd day of a normal menstrual period. Use effective birth control while you are using diclofenac and misoprostol.

Diclofenac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using diclofenac, especially in older adults. You should not use this medicine if you have active bleeding in your stomach or intestines.

Similar Drugs

Brand Name Examples Supplied As Strength
Arthrotec tablet 50 mg-200 mcg75 mg-200 mcg
Generic Examples Supplied As Strength
Diclofenac Sodium-Misoprostol tablet 50 mg-200 mcg75 mg-200 mcg

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