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Frequently Asked Questions
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Pegfilgrastim is used to prevent neutropenia (a lack of certain white blood cells) that is caused by receiving chemotherapy.
Pegfilgrastim is a form of a protein that stimulates the growth of white blood cells that help your body fight against infection.
Pegfilgrastim may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to pegfilgrastim or filgrastim (Neupogen).
Tell your doctor if you have ever had:
- sickle cell disorder;
- kidney disease;
- chronic myeloid leukemia;
- radiation treatment;
- myelodysplasia (also called "preleukemia"); or
- a latex allergy.
Tell your doctor if you are pregnant or breastfeeding.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Pegfilgrastim should not be given within 14 days before or 24 hours after you receive chemotherapy.
Pegfilgrastim is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.
Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.
Carefully follow your doctor's instructions when giving pegfilgrastim to a child who weighs less than 99 pounds (45 kilograms). The correct dose for a child this size cannot be accurately measured using the prefilled syringe.
You may need medical tests to help your doctor determine how long to treat you with pegfilgrastim.
Store the prefilled syringe in its original package in the refrigerator, protected from light. Do not shake or freeze.
Take the syringe out of the refrigerator and let it reach room temperature for 15 to 30 minutes before injecting your dose. If a syringe has become frozen, thaw it in a refrigerator. Do not use any syringe that has been frozen more than one time.
Do not use a Neulasta or Udenyca syringe that has been left at room temperature for longer than 48 hours. Do not use a Fulphila*or *Ziextenzo syringe that has been left at room temperature for longer than 72 hours.
The Neulasta Onpro Injector is a special device placed on the skin that delivers your pegfilgrastim dose at a specific time. You will need to wear the device for 27 hours before the dose begins. The timed dose will then be released from the device slowly over a 45-minute period.
Keep Neulasta Onpro refrigerated until you are ready to wear it. Do not use an Onpro device that has been left out of a refrigerator for longer than 12 hours.
While wearing Neulasta Onpro, you or a caregiver will need to check the device to make sure it is working properly.
Each prefilled syringe or Onpro Injector is for one use only. Throw it away after one use, even if there is still medicine left inside.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
Call your doctor for instructions if you miss an injection, or if you have a problem with the Neulasta Onpro device.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
When using Neulasta Onpro: Avoid traveling, driving, or operating machinery while wearing the device.
Get emergency medical help if you have signs of an allergic reaction: hives, skin rash, sweating; dizziness, warmth or tingly feeling; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.
Capillary leak syndrome is a rare but serious side effect of pegfilgrastim. Call your doctor right away if you have signs of this condition, which may include: decreased urination, tiredness, dizziness or light-headed feeling, trouble breathing, and sudden swelling, puffiness, or feeling of fullness.
Call your doctor at once if you have:
- sudden or severe pain in your left upper stomach spreading up to your shoulder;
- easy bruising, unusual bleeding, purple or red spots under your skin;
- bruising, swelling, or a hard lump where the medicine was injected;
- inflammation of the aorta--fever, tiredness, stomach pain, back pain;
- signs of acute respiratory distress syndrome--fever, shortness of breath, rapid breathing; or
- kidney problems--little or no urination, pink or dark urine, swelling in your face or lower legs.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- bone pain; or
- pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other drugs may affect pegfilgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Your doctor or pharmacist can provide more information about pegfilgrastim.
|Brand Name Examples||Supplied As||Strength|
|Neulasta||solution||6 mg/0.6 mL|
|Neulasta Onpro Kit||solution||6 mg/0.6 mL|