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Frequently Asked Questions
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using desvenlafaxine without first talking to your doctor.
Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant.
Desvenlafaxine is used to treat major depressive disorder.
Desvenlafaxine may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to desvenlafaxine or venlafaxine (Effexor).
Do not use desvenlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.
Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with desvenlafaxine could cause a serious condition called serotonin syndrome.
Tell your doctor if you have ever had:
- heart disease, high blood pressure, high cholesterol, or a stroke;
- bipolar disorder (manic depression);
- depression, suicidal thoughts;
- liver or kidney disease;
- seizures or epilepsy;
- lung or breathing problems;
- a bleeding or blood clotting disorder; or
- low levels of sodium in your blood.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Taking an SNRI antidepressant during late pregnancy could increase your risk of excessive bleeding after you give birth, and may cause serious medical complications in the baby. However, stopping the medicine may not be safe if you have a relapse of depression. Do not start or stop desvenlafaxine without asking your doctor.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of desvenlafaxine on the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
Not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take desvenlafaxine with water at the same time each day, with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
Your blood pressure will need to be checked often.
Your symptoms may not improve for several weeks. You may have unpleasant symptoms if you stop using desvenlafaxine suddenly. Ask your doctor before stopping the medicine.
Part of a tablet shell may appear in your stool but this will not make the medicine less effective.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with desvenlafaxine may cause you to bruise or bleed easily.
Avoid drinking alcohol.
Get emergency medical help if you have signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
- a seizure (convulsions);
- easy bruising or bleeding (nosebleeds, bleeding gums), blood in your urine or stools, coughing up blood;
- blurred vision, eye pain or swelling, or seeing halos around lights;
- cough, chest discomfort, trouble breathing; or
- low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
- dizziness, drowsiness, anxiety;
- increased sweating;
- nausea, decreased appetite, constipation;
- sleep problems (insomnia); or
- decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Using desvenlafaxine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your other medicines, especially a blood thinner (warfarin, Coumadin, Jantoven) or other medicine used to prevents blood clots.
Other drugs may affect desvenlafaxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Your pharmacist can provide more information about desvenlafaxine.
|Brand Name Examples||Supplied As||Strength|
|Khedezla||tablet, extended release||(as base) 100 mg(as base) 50 mg|
|Generic Examples||Supplied As||Strength|
|Desvenlafaxine||tablet, extended release||(as base) 100 mg(as base) 50 mg100 mg50 mg|