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Frequently Asked Questions
You should not use this medicine if you have kidney problems, Addison's disease, high blood levels of calcium or potassium, an allergy to sulfa drugs, or if you are unable to urinate.
Spironolactone has caused tumors in animals but it is not known whether this could occur in people. Do not use this medicine for any condition that has not been checked by your doctor.
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.
Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication also treats high blood pressure (hypertension).
Do not use this medicine for any condition that has not been checked by your doctor.
Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide.
You should not use this medication if you are allergic to hydrochlorothiazide or spironolactone, or if you have:
- kidney disease or urination problems;
- liver disease;
- high levels of calcium or potassium in your blood;
- an allergy to sulfa drugs; or
- Addison's disease (an adrenal gland disorder).
To make sure hydrochlorothiazide and spironolactone is safe for you, tell your doctor if you have ever had:
- cirrhosis or other liver disease;
- severe kidney disease;
- diabetes; or
In animal studies, spironolactone caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Hydrochlorothiazide and spironolactone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Hydrochlorothiazide and spironolactone is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Do not share this medicine with another person, even if they have the same symptoms you have.
While using hydrochlorothiazide and spironolactone, you may need frequent blood tests.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using hydrochlorothiazide and spironolactone.
If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and spironolactone. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include confusion, skin rash, nausea, vomiting, diarrhea, dizziness, and drowsiness.
Drinking alcohol can increase certain side effects of hydrochlorothiazide and spironolactone.
Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and spironolactone, unless your doctor has told you to.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using hydrochlorothiazide and spironolactone.
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out;
- sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising, unusual bleeding, purple or red pinpoint spots under your skin;
- eye pain, vision problems;
- breast swelling and tenderness;
- high potassium--slow heart rate, weak pulse, muscle weakness, tingly feeling;
- low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
- low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
- drowsiness, dizziness, lack of energy;
- leg cramps; or
- itching, hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking this medicine with other drugs that make you dizzy or lower your blood pressure can worsen these effects. Ask your doctor before taking a sleeping pill, opioid pain medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
- heart or blood pressure medicine, especially another diuretic;
- insulin or oral diabetes medicine;
- medicine to prevent a blood clot;
- NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
- steroid medicine--dexamethasone, prednisone, or others.
This list is not complete. Other drugs may interact with hydrochlorothiazide and spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Your pharmacist can provide more information about hydrochlorothiazide and spironolactone.
|Brand Name Examples||Supplied As||Strength|
|Aldactazide||tablet||25 mg-25 mg50 mg-50 mg|
|Generic Examples||Supplied As||Strength|
|Hydrochlorothiazide-Spironolactone||tablet||25 mg-25 mg|